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Antibody design · Protein Design · Binder design

Germinal

Design de novo antibodies against a chosen epitope on a target structure.

Runs the Germinal pipeline, which hallucinates VHH or scFv binders through AlphaFold-Multimer under antibody language model guidance and then filters the trajectories on its structural and sequence criteria. Germinal's own configuration is a set of named Hydra profiles rather than a flat set of flags; this writes a target profile for the submitted structure and selects the matching run and filter profiles for the chosen binder format.

Input

Configure a small job

POST
Comma-separated target residues that define the epitope, for example A56,A57,A58.
Hallucination trajectories attempted; most are discarded by the filters.
The run stops once this many designs have passed every filter.
Ready
Response

JSON result

{
  "status": "Ready for a request"
}