Antibody design · Binder design · Protein Design

mBER

Design VHH (nanobody) binders against a target by backprop through AlphaFold-Multimer.

Runs mBER (Manifold Binder Engineering and Refinement) through its mber-vhh command-line tool, which designs VHH binders with the ColabDesign backpropagation loop against a target structure, optionally steered onto named hotspots, and keeps every trajectory that clears its iPTM and pLDDT filters. scFv design is not exposed by this CLI in the open-source release.

Documentation ↗ Source code ↗

Input

Configure a small job

POST

Job name

Target antigen PDB

Target chains Comma-separated if the target is bound across more than one chain, for example A,B.

Epitope hotspots (optional) Comma-separated target residues, for example A56,A57. Empty lets mBER bind anywhere on the target.

Designs to keep The run stops once this many trajectories have passed the iPTM/pLDDT filters.

Trajectories to attempt Upper bound on attempts if num_accepted is never reached.

Minimum iPTM

Minimum pLDDT

Ready

Response

JSON result

{
  "status": "Ready for a request"
}